Disease Models

Our team has over fifty years of experience with efficacy studies in all of the major therapeutic areas including: Autoimmune Disorders, Cardiovascular, CNS, Infectious Disease, Inflammation, Metabolic Disease and Oncology. We use the most validated and reliable models for testing your compounds and our years of experience can help guide your decision regarding the best model for your application. MuriGenics will also help you develop new animal models tailored to your specific pharmaceutical screening programs. Browse through the therapeutic categories below to take inventory of our capabilities. Models we routinely perform at MuriGenics are highlighted with links to our validated protocols listed to the right. Contact us for information on the additional models listed below or if you would like to propose a new model or customize an existing model to meet your particular research needs. As with all of our In Vivo services, we guarantee continued communication during on-going studies and will contact you directly with any questions or concerns. This helps to guarantee that any data collected is both biologically and clinically reliable and relevant.

Autoimmune Disorders

Diabetes (Type-1)

  • Non-Obese Diabetic (NOD Mice)

Experimental Autoimmune Encephelomyelitis (EAE):

Rheumatoid Arthritis Models:

Cardiovascular

  • Atherosclerosis: Transgenic and Atherogenic Diet
    • ApoE -/-
    • LDLR-/-
    • sPLA2-trangenic
  • Carotid Artery Ligation (mouse)
  • Hypertension
    • Spontaneously Hypertensive Rat (SHR) Model
    • Angiotensin-2 Infusion
    • High-Salt Diet
  • Restenosis Following Carotid Balloon Angioplasty (rat)
  • Chemically-Induced Carotid Thrombus Formation (rat)
  • Thrombosis
    • Tail Bleeding Time
    • Blood Coagulation Time

Central Nervous System & Behavior

  • Parkinson’s Disease by MPTP Injection (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)
  • Behavioral
    • Elevated Plus-Maze
    • Open Field Activity
    • Tail Suspension
    • Startle Response
    • Hang Time

Gastrointestinal Physiology

Infectious Disease

Inflammation

Allotransplantation

Airpouch

Contact Hypersensitivity & Delayed-Type Hypersensitivity

  • Dermal 2,4-Dinitro-1-Fluorobenzene (DNFB)
  • Intradermal Methylated-BSA

Dermal

Hepatitis

  • Non-Lethal LPS/D-GalN Induced Hepatitis (Acute Model)

Inflammatory Bowel Disease (IBD)

Local Inflammation

Peritonitis

  • Thioglycollate, Mineral Oil, or Pristane-Induced

Pulmonary Inflammation (Lung Injury)

Renal Acute Inflammation

  • Unilateral Ureter Obstruction (UUO)
  • High-Protein Diet (rats)

Sepsis

Metabolic Disease

Obesity, Diabetes and Metabolic Syndrome

  • Dietary
    • C57BL/6J or /6N Mouse Diet-Induced Obesity (DIO)
    • Fructose Diet Sprague Dawley Rat
  • Genetically Modified
    • db/db
    • ob/ob
    • Zucker Fatty Diabetic Rat (ZDF)
    • Zucker Fatty Rat

Renal Failure

  • Goto-Kakizaki (GK) Rats Treated with a High-Salt Diet & Angiotensin II

Steatosis

  • Atherogenic Diet (Piagen)
  • C57BL/6J High-Fat Diet
  • ob/ob; db/db
  • NON/ShiLtJ High-Fat Diet
  • Dietary Methionine/Choline Deficient

Oncology

Xenograft Models

  • Tumor Cell Line Model:
    • Prostate: PC3, DU145, LNCaP, 22Rv1
    • Breast: BT474, MCF7, SKBR3, BT 483
    • Colorectal: HT29, SNU C2B, HCT-116
    • Lung: NCI H460, A549, NCI-H2
    • Melanoma: WM115, A375
    • Ovarian: SK-OV3. OvCAR3
    • Pancreatic: BxPC3
    • Glioblastoma: A172
  • Hematopoietic Tumors:
    • MV-4-11, K562, MMI.S

Syngenic Models in Mice Custom Tumor Model Development