Determining the pharmacokinetics (PK) of novel test compounds is essential for approximating efficacy during the drug development and discovery phases. At MuriGenics, we provide a wide-range of murine pharmacokinetic, bioavailability and biodistribution services that can be customized to meet the needs of our clients.
In order to screen for possible gene-compound interactions, MuriGenics provides preclinical pharmacogenetic PK profiling through the use of a variety of strains of rats or mice. In addition, a PK component can be added to a Disease Model study to assess changes within PK parameters during a particular disease state.
As with all of our in vivo services, we guarantee continued communication during on-going studies and will contact you directly with any questions or concerns. This helps to guarantee that any data collected is both biologically and clinically reliable and relevant.
Mice (outbred, inbred, genetically engineered strains, contact us for additional information on a specific strain or with questions regarding strains that may express a specific phenotype of interest)
Rats (implanted catheters available, inquire about strains)
PK Dose Administration
A compound of interest is delivered via one of several routes. Typically, there are 3-5 animals/dose/group. Some studies may require several concentrations of a particular compound of interest or the use of different formulations and vehicles. Routes of administration available for drug delivery include:
- Slow Infusion
- Continuous Infusions (Osmotic or syringe pump)
Sampling Time Points
At various time points set forth in the study protocol, blood samples (tissue samples) will be collected and processed. The number of and distance between time points will be dependent upon the compound, the route of administration, and its half-life.
Biliary pharmacokinetic studies may be conducted to determine biliary excretion and clearance of test articles.
PK Analysis in Disease Models
Since the pharmacokinetics of a compound may change during disease influencing efficacy, PK studies may be performed in conjunction with Disease Models. Contact us to inquire about adding a PK component to one of our available disease models or to discuss a study idea of your own.