Biliary Secretion by Cannulated Bile Duct

Many pharmacological agents and their metabolites are cleared and excreted into bile fluid. Using bile duct cannulation, the amount and rate of biliary drug excretion can be determined. Biliary secretion studies assist in determining the clearance route of a novel compound of interest.

Category(s)

Pharmacokinetic (PK) Study

Species

Rats (Bile duct cannulated)

Basic Methodology

Bile duct cannulated rats can be dosed either p.o., i.v., s.c. or i.p. with a compound of interest. Bile fluid will be collected at set time points, but will not be allowed to drip for longer than 8-hours.

Measurements

General clinical observations, bile fluid collection, blood collection for PK or other analysis

Literature References:

Abdel Salam OM, Baiuomy AR, El-Shenawy SM. (2005) Effect of cysteamine on bile secretion in the rat. Pharmacological Reports; 57(3): 345-51.

Pavankuamr VV, Vinu CA, Mullangi R Srinivas NR. (2007) Preclinical pharmacokinetics and interspecies scaling of ragaglitazar, a novel biliary excreted PPAR dual activator. European Journal of Drug Metabolism and Pharmacokinetics; 32: 29-37.